Certificate in Antibody Stability & Degradation
-- ViewingNowThe Certificate in Antibody Stability & Degradation is a comprehensive course that equips learners with critical skills in the field of biologics. This program focuses on the importance of antibody stability and understanding degradation pathways, which are crucial in drug development and therapeutic applications.
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โข Introduction to Antibody Stability & Degradation: Overview of antibodies, their structure, and function; Importance of antibody stability; Common factors affecting antibody degradation. โข Thermodynamic Stability of Antibodies: Basics of protein thermodynamics; Conformational stability of antibodies; Role of disulfide bonds and hydrophobic interactions in antibody stability. โข Formulation Strategies for Antibody Stability: Excipients selection; pH and ionic strength optimization; Cryopreservation techniques; Formulation development for enhanced stability. โข Forcing Degradation Studies: Stress testing of antibodies; Identification of degradation pathways; Accelerated stability studies; Evaluation of shelf-life. โข Analytical Techniques for Antibody Degradation: Size-exclusion chromatography (SEC); Ion-exchange chromatography (IEX); Capillary electrophoresis (CE); Mass spectrometry (MS). โข Immunogenicity & ADA Formation: Overview of immunogenicity; Factors influencing ADA formation; Immunogenicity assessment methods; Strategies to minimize immunogenicity. โข Case Studies on Antibody Stability & Degradation: Real-world examples of antibody stability challenges; Lessons learned; Best practices for addressing stability concerns.
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