Certificate in Antibacterial Drug Discovery and Design Principles
-- ViewingNowThe Certificate in Antibacterial Drug Discovery and Design Principles is a comprehensive course that equips learners with the essential skills needed in the antibacterial drug discovery industry. This program emphasizes the importance of understanding bacterial pathogenesis, drug discovery strategies, and structure-based design principles.
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โข Introduction to Antibacterial Drug Discovery: Understanding the need for antibacterial drugs, historical context, and current state of antibacterial resistance.
โข Microbiology and Bacterial Pathogenesis: Overview of bacterial structure, growth, and virulence, including common pathogenic bacteria and their drug targets.
โข Target Identification and Validation: Principles and methods for identifying and validating antibacterial drug targets, including target-based screening and phenotypic screening.
โข Medicinal Chemistry for Antibacterial Drug Design: Design and synthesis of antibacterial compounds, focusing on drug-like properties, pharmacokinetics, and pharmacodynamics.
โข Computational Methods in Antibacterial Drug Discovery: Utilization of computational tools for antibacterial drug discovery, including molecular docking, molecular dynamics simulations, and quantitative structure-activity relationship (QSAR) studies.
โข Antibacterial Drug Screening and Assays: Methods for screening antibacterial compounds, including high-throughput screening (HTS), biochemical assays, and whole-cell assays.
โข Preclinical Development of Antibacterial Drugs: Preclinical evaluation of antibacterial compounds, including in vitro and in vivo studies, toxicity testing, and formulation development.
โข Clinical Development of Antibacterial Drugs: Clinical trials for antibacterial drugs, including Phase I-IV trials, regulatory considerations, and market approval process.
โข Resistance Mechanisms and Strategies for Overcoming Antibacterial Resistance: Mechanisms of antibacterial resistance, including target-based resistance, efflux pumps, and biofilm formation, and strategies for overcoming resistance.
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